How does neural tube close




















Nat Rev Genet — Copp A, Greene N Genetics and development of neural tube defects. J Pathol — Juriloff D, Harris M Mouse models for neural tube closure defects. Hum Mol Genet — Beaudin A, Stover P Folate-mediated one-carbon metabolism and neural tube defects: balancing genome synthesis and gene expression.

Nat Rev Neurosci — Copp A Neurulation in the cranial region—normal and abnormal. J Anat — Harris M, Juriloff D An update to the list of mouse mutants with neural tube closure defects and advances toward a complete genetic perspective of neural tube closure.

Prog Neurobiol — Morriss-Kay G Growth and development of pattern in the cranial neural epithelium of rat embryos during neurulation. J Embryol Exp Morphol 65 Suppl — PubMed Google Scholar. Geelen J, Langman J Closure of the neural tube in the cephalic region of the mouse embryo. Anat Rec — Sakai Y Neurulation in the mouse: manner and timing of neural tube closure. Macdonald K, Juriloff D, Harris M Developmental study of neural tube closure in a mouse stock with a high incidence of exencephaly.

Teratology — Golden J, Chernoff G Intermittent pattern of neural tube closure in two strains of mice. Fleming A, Copp A A genetic risk factor for mouse neural tube defects: defining the embryonic basis. Dev Dyn — Morriss G, New D Effect of oxygen concentration on morphogenesis of cranial neural folds and neural crest in cultured rat embryos.

J Embryol Exp Morphol — Waterman R Topographical changes along the neural fold associated with neurulation in the hamster and mouse. Am J Anat — Matsumoto A, Hatta T, Moriyama K, Otani H Sequential observations of exencephaly and subsequent morphological changes by mouse exo utero development system: analysis of the mechanism of transformation from exencephaly to anencephaly.

Anat Embryol Berl — Article Google Scholar. Wood L, Smith M Generation of anencephaly: 1. Aberrant neurulation and 2. Conversion of exencephaly to anencephaly. J Neuropathol Exp Neurol — Eom D, Amarnath S, Fogel J, Agarwala S Bone morphogenetic proteins regulate neural tube closure by interacting with the apicobasal polarity pathway.

Development — Margolis B, Borg J Apicobasal polarity complexes. J Cell Sci — Genes Dev — Dev Biol — Jeong J, McMahon A Growth and pattern of the mammalian neural tube are governed by partially overlapping feedback activities of the hedgehog antagonists patched 1 and Hhip1.

Ribes V, Briscoe J Establishing and interpreting graded Sonic Hedgehog signaling during vertebrate neural tube patterning: the role of negative feedback. Cold Spring Harb Perspect Biol 1:a Nature — Science — Am J Pathol — Keller R Shaping the vertebrate body plan by polarized embryonic cell movements. Wallingford J, Harland R Neural tube closure requires Dishevelled-dependent convergent extension of the midline.

Ueno N, Greene N Planar cell polarity genes and neural tube closure. Nat Genet — Curr Biol — Schoenwolf G, Alvarez I Roles of neuroepithelial cell rearrangement and division in shaping of the avian neural plate.

Sausedo R, Schoenwolf G Cell behaviors underlying notochord formation and extension in avian embryos: quantitative and immunocytochemical studies. Sausedo R, Schoenwolf G Quantitative analyses of cell behaviors underlying notochord formation and extension in mouse embryos.

Tuckett F, Morriss-Kay G The kinetic behaviour of the cranial neural epithelium during neurulation in the rat. Baker P, Schroeder T Cytoplasmic filaments and morphogenetic movement in the amphibian neural tube.

Morriss-Kay G, Tuckett F The role of microfilaments in cranial neurulation in rat embryos: effects of short-term exposure to cytochalasin D. Ybot-Gonzalez P, Copp A Bending of the neural plate during mouse spinal neurulation is independent of actin microfilaments. Kinoshita N, Sasai N, Misaki K, Yonemura S Apical accumulation of Rho in the neural plate is important for neural plate cell shape change and neural tube formation.

Mol Biol Cell — Nishimura T, Takeichi M Shroom3-mediated recruitment of Rho kinases to the apical cell junctions regulates epithelial and neuroepithelial planar remodeling. Neuron — Gurniak C, Perlas E, Witke W The actin depolymerizing factor n-cofilin is essential for neural tube morphogenesis and neural crest cell migration. J Neurosci — Mol Cell Neurosci — Cell — Curr Biol R—R Mech Dev — Chen Z, Behringer R twist is required in head mesenchyme for cranial neural tube morphogenesis.

Zhao Q, Behringer R, de Crombrugghe B Prenatal folic acid treatment suppresses acrania and meroanencephaly in mice mutant for the Cart1 homeobox gene. Zohn I, Anderson K, Niswander L The Hectd1 ubiquitin ligase is required for development of the head mesenchyme and neural tube closure.

Jacobson A, Moury J Tissue boundaries and cell behavior during neurulation. Alvarez I, Schoenwolf G Expansion of surface epithelium provides the major extrinsic force for bending of the neural plate. J Exp Zool — Hackett D, Smith J, Schoenwolf G Epidermal ectoderm is required for full elevation and for convergence during bending of the avian neural plate. Bray S, Kafatos F Developmental function of Elf an essential transcription factor during embryogenesis in Drosophila.

Nat Med — Pyrgaki C, Liu A, Niswander L Grainyhead-like 2 regulates neural tube closure and adhesion molecule expression during neural fold fusion. Lee H, Adler P The grainy head transcription factor is essential for the function of the frizzled pathway in the Drosophila wing. Dev Cell — EMBO J — Dworkin S, Jane S, Darido C The planar cell polarity pathway in vertebrate epidermal development, homeostasis and repair.

Organogenesis — Geelen J, Langman J Ultrastructural observations on closure of the neural tube in the mouse. J Cell Biol — Ray H, Niswander L Mechanisms of tissue fusion during development. Hatta K, Takeichi M Expression of N-cadherin adhesion molecules associated with early morphogenetic events in chick development.

Chen B, Hales B Antisense oligonucleotide down-regulation of E-cadherin in the yolk sac and cranial neural tube malformations. Biol Reprod — Mol Cell Biol — Cancer Res — Int J Dev Biol — Tan S, Morriss-Kay G Analysis of cranial neural crest cell migration and early fates in postimplantation rat chimaeras.

Biol Rev 26 1 — Fuchs Y, Steller H Programmed cell death in animal development and disease. Miura M Active participation of cell death in development and organismal homeostasis. Dev Growth Differ — Cell 4 — Neuron 22 4 — Rosenblatt J, Raff M, Cramer L An epithelial cell destined for apoptosis signals its neighbors to extrude it by an actin- and myosin-dependent mechanism. Sci Signal 3 :ra Iseki S Disintegration of the medial epithelial seam: is cell death important in palatogenesis?

Tait S, Green D Caspase-independent cell death: leaving the set without the final cut. Although there are no official guidelines recommending that mothers-to-be continue to take folic acid, throughout the whole pregnancy, there is not thought to be any harm in continuing to take a B9 supplement. It is advisable that all women of child-bearing age take a folic acid supplement just in case they become unexpectedly pregnant. Trying to get pregnant? The importance of the neural tube and folic acid As you enter week 5 of your pregnancy you can be assured that although your baby is only fractionally larger than a sesame seed, its growth and development are taking place at an incredibly rapid rate.

The importance of the neural tube The neural tube is a hollow structure of tissue which later develops into the brain, spinal cord and nervous system. Neural tube defects If there are problems with the development of the neural tube, this can result in defects affecting the brain, spine, or spinal cord. The following are the most common neural tube defects: Spina bifida — occurs as a result of a fault in the spinal cord and surrounding bones leaving a gap in the spine. Detection In some cases neural tube defects may be detected during your routine ultrasound scan at around 12 weeks.

Sign up and get started Already a member? There has been a problem with the registration process. The neural tube forms the early brain and spine. These types of birth defects develop very early during pregnancy, often before a woman knows she is pregnant. The two most common NTDs are spina bifida a spinal cord defect and anencephaly a brain defect. If you have already had an NTD-affected pregnancy, CDC recommends consuming mcg of folic acid each day, even if you are not planning to become pregnant.

When planning to become pregnant, CDC recommends consuming 4, mcg of folic acid each day starting 1 month before becoming pregnant and during the first 3 months of pregnancy.

Prevention and Risk Factors. Treatments and Therapies. Related Issues. Statistics and Research. Clinical Trials. Article: Current levels of coverage of iron and folic acid fortification are Article: Timeliness of postnatal surgery in newborns with open neural tube defects Neural Tube Defects -- see more articles.



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